1st Avenue Central includes the area between Gateway Drive and North 17th Place. In its west are vacant lots, zoned General Commercial, and in its east are single-family residences, zoned as Office/Retail. The Medical Arts facilities are within the Institutional zoning. Current businesses include 30 medical offices, one automotive repair shop, and two commercial establishments.
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Like 1st Avenue West, it is only indirectly accessible to Gateway Drive via a 2nd Avenue spur, and from Thomason Drive. Its other primary access point is North 20th Street. A railroad crossing is located on Thomason Drive.
External to 1st Avenue Central is EAMC, a significant regional employer and destination. Thomason Drive is a primary connector to Gateway Drive and the Tiger Town commercial district to the south. Development along this road includes banks, a childcare facility, a storage facility, and residential development.
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